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Mammoto A, Ingber DE. Cytoskeletal control of growth and cell fate switching. Curr Opin Cell Biol. 2009 Sep 7. [Epub ahead of print]

Derda R, Laromaine A, Mammoto A, Tang SK, Mammoto T, Ingber DE, Whitesides GM. Paper-supported 3D cell culture for tissue-based bioassays. Proc Natl Acad Sci U S A. 2009 Oct 21. [Epub ahead of print]

Czakó B, Kürti L, Mammoto A, Ingber DE, Corey EJ. Discovery of potent and practical antiangiogenic agents inspired by cortistatin A. J Am Chem Soc. 2009 Jul 1;131(25):9014-9.

Thodeti CK, Matthews B, Ravi A, Mammoto A, Ghosh K, Bracha AL, Ingber DE. TRPV4 channels mediate cyclic strain-induced endothelial cell reorientation through integrin-to-integrin signaling. Circ Res. 2009 May 8;104(9):1123-30. Epub 2009 Apr 9.

Discher D, Dong C, Fredberg JJ, Guilak F, Ingber D, Janmey P, Kamm RD, Schmid-Schönbein GW, Weinbaum S. Biomechanics: Cell Research and Applications for the Next Decade. Ann Biomed Eng. 2009 May;37(5):847-59. Epub 2009 Mar 4.

Ostuni E, Whitesides GM, Ingber DE, Chen CS. Using Self-Assembled Monolayers to Pattern ECM Proteins and Cells on Substrates. Methods Mol Biol. 2009;522:183-94.

Mammoto A, Connor KM, Mammoto T, Yung CW, Huh D, Aderman CM, Mostoslavsky G, Smith LE, Ingber DE. A mechanosensitive transcriptional mechanism that controls angiogenesis. Nature. 2009 Feb 26;457(7233):1103-8.

Yung C, Fiering J, Mueller AJ, Ingber DE. Micromagnetic – Microfluidic Blood Cleansing Microdevice. Lab Chip. 2009 May 7;9(9):1171-7. Epub 2009 Feb 18.

Wang N, Tytell JD, Ingber DE. Mechanotransduction at a distance: mechanically coupling the extracellular matrix with the nucleus. Nat Rev Mol Cell Biol. 2009 Jan;10(1):75-82.

Alenghat FJ, Tytell JD, Thodeti CK, Derrien A, Ingber DE. Mechanical control of cAMP signaling through integrins is mediated by the heterotrimeric Galphas protein. J Cell Biochem. 2009 Jan 23.106(4):529-538. [Epub ahead of print]

Dimitrije Stamenovi and Donald E. Ingber. Tensegrity-guided self assembly: from molecules to living cells. Soft Matter. Vol5 | Number6 | 21 March 2009| Pages 1093-1296


Chen CS, Ingber DE. Tensegrity und Mechanoregulation: Vom Skelett zum Zytoskelett. Osteopathische Medizin, Zeitschrift für ganzheitliche Heilverfahren Volume 9, Issue 4, November 2008, Pages 4-17.

Mammoto A, Sero JE, Mammoto T, Ingber DE. Methods for studying mechanical control of angiogenesis by the cytoskeleton and extracellular matrix. Methods Enzymol. 2008;443:227-59.

Shimizu A, Mammoto A, Italiano JE, Pravda E, Dudley AC, Ingber DE, Klagsbrun M. ABL2/ARG tyrosine kinase mediates SEMA3F-induced RhoA inactivation and cytoskeleton collapse in human glioma cells. J Biol Chem. 2008 Oct 3;283(40):27230-8. Epub 2008 Jul 25.

Yu CH, Haller K, Ingber DE, Nagpat R. Morpho: A Self-deformable Modular Robot Inspired by Cellular Structure. IROS. - in press.

Hoffmann M, Chang HH, Huang S, Ingber DE, Loeffler M, Galle J. Noise-driven stem cell and progenitor population dynamics. PLoS ONE. 2008 Aug 13;3(8):e2922.

Ingber DE. Tensegrity and mechanotransduction. Journal of Bodywork and Movement Therapies. Volume 12, Issue 3, July 2008, Pages 198-200

Ghosh K, Thodeti CK, Dudley D, Mammoto A, Klagsbrun M, and Ingber DE. Tumor derived endothelial cells exhibit aberrant Rho-mediated mechanosensing and abnormal angiogenesis in vivo. Proc. Natl. Acad. Sci. U. S. A. 2008 August 12. Vol 105(32): 11305-11310.

Luo Y, Xu X, Lele T, Kumar S and Ingber DE. A multimodular tensegrity model of an actin stress fiber. J Biomech. 2008 Aug 7;41(11):2379-87. Epub 2008 Jul 15.

Gee EPS, Ingber DE and Stultz CM. Fibronectin unfolding revisited: modeling cell traction-mediated unfolding of the tenth type-III repeat. PLoS One. 2008;3(6):e2373. Epub 2008 Jun 11.

Chang HH, Hemberg M, Barahona M, Ingber DE, Huang S. Transcriptome-wide noise controls lineage choice in mammalian progenitor cells. Nature. 2008 May 22;453(7194):544-7.

Ingber DE. Can cancer be reversed by engineering the tumor microenvironment? Semin Cancer Biol. 2008 Apr 1. [Epub ahead of print]

Ingber DE. Tensegrity-based mechanosensing from macro to micro. Prog Biophys Mol Biol. 2008 Jun-Jul;97(2-3):163-79. Epub 2008 Feb 13.

Ingber DE. From Molecular Cell Engineering to Biologically Inspired Engineering. Cellular and Molecular Bioengineering. Received 22 January 2008; accepted 30 January 2008.

Mammoto A, Mammoto T, Ingber DE. Rho signaling and mechanical control of vascular development. Curr Opin Hematol. 2008 May;15(3):228-234.

Fredenburgh LE, Liang OD, Macias AA, Polte TR, Liu X, Riascos DF, Chung SW, Schissel SL, Ingber DE, Mitsialis SA, Kourembanas S, Perrella MA. Absence of Cyclooxygenase-2 Exacerbates Hypoxia-Induced Pulmonary Hypertension and Enhances Contractility of Vascular Smooth Muscle Cells. Circulation. 2008 Apr 22;117(16):2114-22. Epub 2008 Apr 7.

Lele TP, Thodeti CK, Pendse J, Ingber DE. Investigating complexity of protein-protein interactions in focal adhesions. Biochem Biophys Res Commun. 2008 May 9;369(3):929-34. Epub 2008 Mar 10.

Xia N, Thodeti CK, Hunt TP, Xu Q, Ho M, Whitesides GM, Westervelt R, Ingber DE. Directional control of cell motility through focal adhesion positioning and spatial control of Rac activation. FASEB J. 2008 Jun;22(6):1649-59. Epub 2008 Jan 7.

Nauli SM, Kawanabe Y, Kaminski JJ, Pearce WJ, Ingber DE, Zhou J. Endothelial Cilia Are Fluid Shear Sensors That Regulate Calcium Signaling and Nitric Oxide Production Through Polycystin-1. Circulation. 2008 Mar 4;117(9):1161-71. Epub 2008 Feb 19.


Mannix RJ, Kumar S, Cassiola F, Montoya-Zavala M, Feinstein E, Prentiss M, Ingber DE. Nanomagnetic actuation of receptormediated signal transduction. Nature Nanotechology. Dec. 2007.

Chen CS. Remote control of living cells. Nature Nanotechology - News and Views. 2007.

Wilson NR, Ty MT, Ingber DE, Sur M, Liu G. Synaptic reorganization in scaled networks of controlled size. J Neurosci. 2007 Dec 12;27(50):13581-9.

Pietramaggiori G, Liu P, Scherer SS, Kaipainen A, Prsa MJ, Mayer H, Newalder J, Alperovich M, Mentzer SJ, Konerding MA, Huang S, Ingber DE, Orgill DP. Tensile Forces Stimulate Vascular Remodeling and Epidermal Cell Proliferation in Living Skin. Ann Surg. 2007 Nov;246(5):896-902.

Ghosh K, Ingber DE. Micromechanical control of cell and tissue development: Implications for tissue engineering. Adv Drug Deliv Rev. 59(2007) 1306-1318.

Stamenovic D, Rosenblatt N, Montoya-Zavala M, Matthews BD, Hu S, Suki B, Wang N, Ingber DE. Rheological Behavior of Living Cells is Timescale Dependent. Biophys J. 2007 Oct 15;93(8):L39-41. Epub 2007 Aug 10.

Parker KK, Ingber DE. Extracellular matrix, mechanotransduction and structural hierarchies in heart tissue engineering. Philos Trans R Soc Lond B Biol Sci. 2007 Aug 29;362(1484):1267-79.

Mammoto T, Parikh SM, Mammoto A, Gallagher D, Chan B, Mostoslavsky G, Ingber DE, Sukhatme VP. Angiopoietin-1 requires p190RhoGAP to protect against vascular leakage in vivo. J Biol Chem. 2007 Aug 17;282(33):23910-23918. Epub 2007 Jun 11.

Ingber DE, Levin M. What lies at the interface of regenerative medicine and developmental biology? Development. 2007 Jul;134(14):2541-7. Epub 2007 Jun 6.

Maliackal Poulo Joy, Donald E Ingber, and Sui Huang. Chaotic mean field dynamics of a Boolean network with random connectivity. International Journal of Modern Physics C (IJMPC) 2007 Vol 18(9): 1459-1473.

Chen Z, Naveiras O, Balduini A, Mammoto A, Conti MA, Adelstein RS, Ingber D, Daley GQ, Shivdasani RA. The May-Hegglin anomaly gene Myh9 is a negative regulator of platelet biogenesis modulated by the Rho-ROCK pathway. Blood. 2007 Jul 1;110(1):171-9. Epub 2007 Mar 28.

Polte TR, Shen M, Karavitis J, Montoya M, Pendse J, Xia S, Mazur E, Ingber DE. Nanostructured magnetizable materials that switch cells between life and death. Biomaterials. 2007 Jun;28(17):2783-90. Epub 2007 Feb 15.

Huang S and Ingber DE. A non-genetic basis for cancer progression and metastasis: self-organizing attractors in cell regulatory networks. Breast Disease. 26(2007) 27-54.

Mammoto A, Huang S, Ingber DE. Filamin links cell shape and cytoskeletal structure to Rho regulation by controlling accumulation of p190RhoGAP in lipid rafts. J Cell Sci. 2007 Feb 1;120(Pt 3):456-67. Epub 2007 Jan 16.

Dandapani SV, Sugimoto H, Matthews BD, Kolb RJ, Sinha S, Gerszten RE, Zhou J, Ingber DE, Kalluri R, Pollak MR. alpha -actinin-4 is required for normal podocyte adhesion. J Biol Chem. 2007 Jan 5;282(1):467-77.

Book Chapter

Lele T, Sero J, Matthews BD, Kumar S, Xia S, Montoya-Zavala M, Polte T, Overby DR, Wang N and Ingber DE. Tools to study cell mechanotransduction. In: Wang Y, Discher D., eds., Methods in Cell Biology, San Diego: Elsevier Press, 2007; 441-472.

Matthews BD, Thodeti CK and Ingber DE. Integrin-dependent force transmission to mechanosensitive ion channels. In: Hammill O, eds., Mechanosensitive Ion Channels, San Diego: Elsevier Press, 2007; 59-85.

Ingber DE. Tensegrity: the architecture of life. In: Dhambre J, ed, Proceedings of the College de Philosophie, on "The Architecture of Life: From Plato to Tensegrity", Brepols Publishers 2007; Pairs, France.


Guo YC, Eichler GS, Feng Y, Ingber DE, Huang S. Towards a Holistic, Yet Gene-Centered Analysis of Gene Expression Profiles: A Case Study of Human Lung Cancers. Journal of Biomedicine and Biotechnology. 2006, Pages 1–11.

Ingber DE, Mow VC, Butler D, Niklason L, Huard J, Mao J, Yannas I, Kaplan D, Vunjak-Novakovic G. Tissue engineering and developmental biology: going biomimetic. Tissue Eng. 2006 Dec;12(12):3265-83.

Alsberg E, Feinstein E, Joy MP, Prentiss M, Ingber DE. Magnetically-Guided Self-Assembly of Fibrin Matrices with Ordered Nano-Scale Structure for Tissue Engineering. Tissue Eng. Nov 2006, Vol. 12, No. 11: 3247-3256.

Xia N, Hunt TP, Mayers BT, Alsberg E, Whitesides GM, Westervelt RM, Ingber DE. Combined microfluidic-micromagnetic separation of living cells in continuous flow. Biomed Microdevices. 2006 Dec;8(4):299-308.

Sharp ZD, Mancini MG, Hinojos CA, Dai F, Berno V, Szafran AT, Smith KP, Lele TT, Ingber DE, Mancini MA. Estrogen-receptor-{alpha} exchange and chromatin dynamics are ligand- and domain-dependent. J Cell Sci. 2006 Oct 1;119(Pt 19):4101-16.

Yokouchi K, Numaguchi Y, Kubota R, Ishii M, Imai H, Murakami R, Ogawa Y, Kondo T, Okumura K, Ingber DE, Murohara T. 1-Caldesmon Regulates Proliferation and Migration of Vascular Smooth Muscle Cells and Inhibits Neointimal Formation After Angioplasty. Arterioscler Thromb Vasc Biol. 2006 Oct;26(10):2231-7. Epub 2006 Aug 3.

Lele T, Wagner SR, Nickerson JA, Ingber DE. Methods for measuring rates of protein binding to insoluble scaffolds in living cells: Histone H1-chromatin interactions. J Cell Biochem. 2006 Dec 1;99(5):1334-42.

Brangwynne CP, MacKintosh FC, Kumar S, Geisse NA, Talbot J, Mahadevan L, Parker KK, Ingber DE, Weitz DA. Microtubules can bear enhanced compressive loads in living cells because of lateral reinforcement. J. Cell Biol. 2006 173 (5): 733-741.

Ingber DE. Cellular mechanotransduction: putting all the pieces together again. FASEB J. 2006 20: 811-827.

Nauli SM, Rossetti S, Kolb RJ, Alenghat FJ, Consugar MB, Harris PC, Ingber DE, Loghman-Adham M, Zhou J. Loss of polycystin-1 in human cyst-lining epithelia leads to ciliary dysfunction. J Am Soc Nephrol. 2006 Apr;17(4):1015-25.

Lele TP, Ingber DE. A mathematical model to determine molecular kinetic rate constants under non-steady state conditions using fluorescence recovery after photobleaching (FRAP). Biophys. Chem. 2006; 120:32-35.

Lele TP, Pendse J, Kumar S, Salanga M, Karavitis J, Ingber DE. Mechanical forces alter zyxin unbinding kinetics within focal adhesions of living cells. J Cell Physiol. 2006;207(1):187-194.

Chang HH, Oh PY, Ingber DE, Huang S. Multistable and multistep dynamics in neutrophil differentiation. BMC Cell Biol. 2006 Feb 28;7(1):11

Sanchez-Esteban J, Wang Y, Filardo EJ, Rubin LP, Ingber DE. Integrins beta1, alpha6, and alpha3 contribute to mechanical strain-induced differentiation of fetal lung type II epithelial cells via distinct mechanisms. Am J Physiol Lung Cell Mol Physiol. 2006 Feb;290(2):L343-50. Epub 2005 Sep 16.

Kumar S, Maxwell IZ, Heisterkamp A. Polte TR, Lele T, Salanga M, Mazur E, Ingber DE. Viscoelastic retraction of single living stress fibers and its impact on cell shape, cytoskeletal organization and extracellular matrix mechanics. Biophys. J. 2006 May 15;90(10):3762-73. Epub 2006 Feb 24.

Ingber DE. Mechanical control of tissue morphogenesis during embryological development. Intl. J. Dev. Biol. 2006;50(2-3):255-66.

Matthews BD, Overby DR , Mannix R, Ingber DE. Cellular adaptation to mechanical stress: role of integrins, Rho, cytoskeletal tension and mechanosensitive ion channels. J. Cell Sci. 2006 Feb 1;119(Pt 3):508-18.

Lele TP, Thodeti CK, Ingber DE. Force meets chemistry: Analysis of mechanochemical conversion in focal adhesions using fluorescence recovery after photobleaching. J Cell Biochem. 2006 Apr 15; 97(6):1175-83.

Book Chapter

Brock A and Ingber DE. Control of Cell Motility by the Cytoskeleton and Extracellular Matrix. In Shepro D and D’Amore P, eds. Encyclopedia of the Microvasculature, San Diego: Elsevier 2006 pp 13-17.

Stamenovic D, Wang N, Ingber DE. Cellular tensegrity models in cell-substrate interactions. In: King MR, eds. Advances in Cellular Engineering: Micromechanics at the Biomolecular Interface. Kerala, India: Research Signpost Publishing 2006, pp.81-104.

Huang S, Sultan C, Ingber DE. Tensegrity, Dynamic Networks and Complex Systems Biology: Emergence in Structural and Information Networks within Living Cells. In: Deisboeck TS, Kresh JY and Kepler TB, eds. Complex Systems Science in Biomedicine, New York: Kluwer Academic Publishers 2006.

Ingber DE. The Architecture of Life. In: Beesley P., Hirosue S., Ruxton J., Trankle M. and Turner C., eds, Responsive Architectures: Subtle Technologies 2006, Riverside Architectural Press. 2006; 18-21.

Stamenovic D, Wang N, Ingber DE. Tensegrity architecture and the mammalian cell cytoskeleton. In: Sih CG, ed., Multiscaling in Molecular and Continuum Mechanics: Integration of Time and Size from Macro to Nano, New York, NY: Springer, 2006.


Brock AL and Ingber DE. Control of the direction of lamellipodia extension through changes in the balance between Rac and Rho activities. Mol. Cell Biomech. 2005;2(3):135-144.

Barnes CM, Huang S, Kaipainen A, Sanoudou D, Chen EJ, Eichler GS, Guo Y, Yu Y, Ingber DE, Mulliken JB, Beggs AH, Folkman J, Fishman SJ. Evidence by molecular profiling for a placental origin of infantile hemangioma. Proc Natl Acad Sci U S A. 2005 Dec 27;102(52):19097-102. Epub 2005 Dec 19.

Huang S, Ingber DE. Cell tension, matrix mechanics, and cancer development. Cancer Cell. 8(3):175-176. 2005 Sep.

Alon R, Feigelson SW, Rose D, Schmitz J, Manevich E, Overby DR, Winter E, Grabovsky V,Shinder V, Matthews BD, Sokolovsky-Eisenberg M, Ingber DE, Benoit M, Ginsberg MH. Integrin alpha4beta1 (VLA4)-dependent adhesion strengthening under mechanical strain is regulated by paxillin association with the alpha4 cytoplasmic domain. J. Cell Biol. 2005 Dec 19;171(6):1073-84.

Lee H, Liu Y, Alsberg E, Ingber DE, Westervelt RM and Ham D. An IC/Microfluidic hybrid microsystem for 2D magnetic manipulation of individual biological cells. IEEE Int. Solid State Circuits 2005: Session 4:4.3

Ingber DE. Mechanical control of tissue growth: Function follows form. Proc Natl Acad Sci U S A. 2005 Aug 16;102(33):11571-2. Epub 2005 Aug 9.

Ingber DE. Tissue adaptation to mechanical forces in healthy, injured and aging tissues. Scand J Med Sci Sports. 2005 Aug;15(4):199-201.

Huang S, Brangwynne CP, Parker KK, Ingber DE. Symmetry-breaking in mammalian cell cohort migration during tissue pattern formation: Role of random-walk persistence. Cell Motil Cytoskeleton. 2005 Aug;61(4):201-13.

Alex Heisterkamp, Iva Z. Maxwell, Eric Mazur, Jean M. Underwood, Jeffrey A. Nickerson, Sanjay Kumar, and Donald E. Ingber. Pulse energy dependence of subcellular dissection by femtosecond laser pulses. Optics Express 13(10): 3690-3696. 2005.

Nan Shen, Dabajyoti Datta, Chris B. Schaffer, Philip LeDuc, Donald E.Ingber, Eric Mazur. Ablation of cytoskeletal filaments and mitochondria in live cells using a femtosecond laser nanoscissor. MCB 2(1): 17-25. 2005.

Darryl R. Overby, Benjamin D. Matthews, Eben Alsberg and Donald E. Ingber. Novel dynamic rheological behavior of individual focal adhesions measured within single cells using electromagnetic pulling cytometry. Acta Biomaterialia 1(3): 295-303, May 2005.

Short SM, Derrien A, Narsimhan RP, Lawler J, Ingber DE, Zetter BR. Inhibition of endothelial cell migration by thrombospondin-1 type-1 repeats is mediated by beta1 integrins. J Cell Biol. 168(4):643-653. Feb. 14, 2005.

Huang S, Eichler GS, Bar-Yam Y, Ingber DE. Cell Fates as High-Dimensional Attractor States of a Complex Gene Regulatory Network. Phys Rev Lett. 94(12): 128701, 2005.

Moore KA, Polte T, Huang S, Shi B, Alsberg E, Sunday ME, Ingber DE. Control of basement membrane remodeling and epithelial branching morphogenesis in embryonic lung by Rho abd cytoskeletal tension. Dev. Dynamics 232:268-281, 2005.

Joy MP, Brock A, Ingber DE, Huang S. High betweenness proteins in the yeast protein interaction network. J Biomed Biotechnol. 2005(2):96-103, 2005

Book Chapter

Heisterkamp A, Maxwell IZ, Kumar S, Underwood JM, Nickerson JA, Ingber DE and Mazur E. Nanosurgery in live cells using ultrashort laser pulses in Proc. SPIE Vol. 5695, p. 230-235; 2005, Optical Interactions with Tissue and Cells XVI; Steven L. Jacques, William P. Roach; Eds.

Ingber DE, Huang S. A complex systems approach to understand how cells control their shape and make cell fate decisions. In: Jorde, LB, Little P, Dunn, M, Subramaniam S, eds. Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics London: John Wiley, epub 2005 April 15.


Donald E. Ingber. Mechanochemical Basis of Cell and Tissue Regulation. N.A.E. Bridge Volume 34, Number 3 Page 4~10 - Fall 2004

Alenghat FJ, Nauli SM, Kolb R, Zhou J, Ingber DE. Global cytoskeletal control of mechanotransduction in kidney epithelial cells. Exp Cell Res. 301(1):23-30. Nov 15,2004.

Benjamin D. Matthews, David A. LaVan, Darryl R. Overby, John Karavitis, Donald E. Ingber. Electromagnetic needles with submicron pole tip radii for nanomanipulation of biomolecules and living cells. Applied Physics Letters 85, 2968-2970. (October 25, 2004)

Saxena V, Hwang CW, Huang S, Eichbaum Q, Ingber D, Orgill DP. Vacuum-Assisted Closure: Microdeformations of Wounds and Cell Proliferation. Plast Reconstr Surg. 114(5):1086-1096; discussion 1097-1098.(2004 Oct.)

Lele T, Oh P, Nickerson JA, Ingber DE. An improved mathematical model for determination of molecular kinetics in living cells with FRAP. Mechanics & Chemistry of Biosystems Vol. 1, No. 3, pp.181-190 (2004).

Overby DR, Alenghat FJ, Montoya-Zavala M, Bei HC, Oh P, Karavitis J, Ingber DE. Magnetic Cellular Switches. IEEE Transactions on Magnetics Vol. 40, No. 4, July 2004

Sultan C, Stamenovic D, Ingber DE. A computational tensegrity model predicts dynamic rheological behaviors in living cells. Ann. Biomed Engin. 32: 520-530 (2004).

Mammoto A, Huang S, Moore K, Oh P, Ingber DE. Role of RhoA, mDia, and ROCK in cell shape-dependent control of the Skp2-p27kip1 pathway and the G1/S transition. J Biol Chem. 279(25): 26323-30: (2004 Jun 18)

Ingber DE. The Mechanochemical Basis of Cell and Tissue Regulation. Mechanics & Chemistry of Biosystems Vol. 1, No. 1, pp.53-68 (2004).

Thomas R. Polte, Gabriel S. Eichler, Ning Wang, Donald E. Ingber Extracellular matrix controls myosin light chain phosphorylation and cell contractility through modulation of cell shape and cytoskeletal prestress. Am J Physiol Cell Physiol 286: C518–C528 (2004).

Benjamin D. Matthews, Darryl R. Overby, Francis J. Alenghat, John Karavitis, Yasuchi Numaguchi, Philip G. Allen, Donald E. Ingber. Mechanical properties of individual focal adhesions probed with a magnetic microneedle. Biochemical and Biophysical Research Communications 313: 758?64 (2004).

Book Chapter

Alsberg E, Moore K, Huang S, Polte T, Ingber DE. The mechanical and cytoskeletal basis of lung morphogenesis. In: Massaro D, et al., eds. Lung Development and Regeneration. Vol. 190. New York, NY: Marcel Dekker, Inc., 2004: 247-274.


Ingber DE. Mechanobiology and diseases of mechanotransduction. Ann Med. 2003;35(8):564-77.

Eichler GS, Huang S, Ingber DE. Gene Expression Dynamics Inspector (GEDI): for integrative analysis of expression profiles. Bioinformatics. 2003 Nov 22;19(17):2321-2.

Numaguchi Y, Huang S, Polte TR, Eichler GS, Wang N, Ingber DE. Caldesmon-dependent switching between capillary endothelial cell growth and apoptosis through modulation of cell shape and contractility. Angiogenesis. 6(1):55-64 (2003).

Chen CS, Alonso JL, Ostuni E, Whitesides GM, Ingber DE. Cell shape provides global control of focal adhesion assembly. Biochem Biophys Res Commun. 2003 Jul 25;307(2):355-61.

Brock A, Huang S, Ingber DE. Identification of a distinct class of cytoskeleton-associated mRNAs using microarray technology. BMC Cell Biol. 2003 Jul 8;4(1):6.

Hu S, Chen J, Fabry B, Numaguchi Y, Gouldstone A, Ingber DE, Fredberg JJ, Butler JP, Wang N. Intracellular stress tomography reveals stress focusing and structural anisotropy in cytoskeleton of living cells. Am J Physiol Cell Physiol. 2003 Nov;285(5):C1082-90.

Stamenovic D, Ingber DE. Models of cytoskeletal mechanics of adherent cells. Biomech Model Mechanobiol. 2002 Jun;1(1):95-108.

Brock A, Chang E, Ho C, LeDuc P, Jiang X, Whitesides GM, Ingber DE. Geometric determinants of directional cell motility revealed using microcontact printing. Langmuir 19: 1611-1617 (2003).

Ingber DE. Tensegrity II. How structural networks influence cellular information processing networks. J. Cell Sci. 116: 1397-1408 (2003).

Ingber DE.Tensegrity I. Cell structure and hierarchical systems biology. J. Cell Sci. 116: 1157-1173 (2003).

Ingber DE. Mechanosensation through integrins: Cells act locally but think globally.Proc. Natl. Acad. Sci. U.S.A. 100:1472-1474 (2003).

Takayama S, Ostuni E, LeDuc P, Naruse K, Ingber DE, GW. Whitesides. Selective Chemical Treatment of Cellular Microdomains Using Multiple Laminar Streams. Chem. Biol. 10(2): 123-130 (2003).

Nauli SM, Alenghat FJ, Luo Y, Williams E, Vassilev P, Li X, Elia AE, Lu W, Brown EM, Quinn SJ, Ingber DE, Zhou J. Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells. Nature Genet. 33(2): 129-137 (2003).


Ingber DE. Mechanical Signaling and the Cellular Response to Extracellular Matrix in Angiogenesis and Cardiovascular Physiology. Circ. Res. 91: 877-887 (2002).

Ingber DE. Cancer as a disease of epithelia-mesenchymal interactions and extracellular matrix regulation. Differentiation 70: 547-560 (2002).

Ingber DE. Mechanical signaling. Ann. N. Y. Acad. Sci. 961: 162-163 (2002).

Alenghat FJ, Ingber DE. Mechanotransduction: all signals point to cytoskeleton, matrix, and integrins. Sci. STKE. 2002(119):PE6. Review. (Feb 12, 2002).

Damsky C, Heidaran M, Bottaro D, Crossin K, Ducy P, Ingber DE. Molecular Signaling: Breakout Session Summary. Ann. N.Y. Acad. Sci. 961: 164-167 (2002).

Castedo M, Roumier T, Blanco J, Larochette N, Ferri K, Barretina J, Andreau K, Perfettini JL, Amendola A, Nardacci R, Leduc P, Ingber DE, Druillenec S, Roques B, Este JA, Modjtahedi N, Piacentini M, Kroemer G. Sequential Involvement of Cdk1, mTOR and p53 in Apoptosis Induced by the Human Immunodeficiency Virus-1 Envelope. EMBO J. 21: 4070-4080 (2002).

Parker KK, Brock AL, Brangwynne C, Mannix RJ, Wang N, Ostuni E, Geisse N, Adams JC, Whitesides GM, Ingber DE. Directional control of lamellipodia extension by constraining cell shape and orienting cell tractional forces. FASEB J. 16: 1195-1204 (2002).

Moore KA, Huang S, Kong Y, Sunday ME, Ingber DE. Control of embryonic lung branching morphogenesis by the Rho activator, cytotoxic necrotizing factor 1. J. Surg. Res. 104: 95-100 (2002).

Wang N, Ostuni E, Ingber DE, Whitesides GM. Micropatterning cell traction in living cells. Cell Motil. Cytoskeleton 52: 97-106 (2002).

Stamenovic D., Ingber DE. Models of cytoskeletal mechanics and adherent cells. Biomechanics and Modeling in Mechanobiology 1: 95-108 (2002).

Huang S, Ingber DE. A discrete cell cycle checkpoint in late G1 that is cytoskeleton dependent and MAP kinase (Erk) - independent. Exp. Cell Res. 275: 255-64 (2002).

Jiang X, Takayama S, Qian X, Ostuni E, Wu H, Bowden N, LeDuc P, Ingber DE, GW. Whitesides. Controlling mammalian cell spreading and cytoskeletal arrangement with conveniently fabricated continuous wavy featureson poly(dimethylsiloxane) Langmuir 18: 3273-3280 (2002).

Goldmann WH, Ingber DE. Intact vinculin protein is required for control of cell shape, cell mechanics, and rac-dependent lamellipodia formation. Biochem. Biophys. Res. Comm. 290: 749-755 (2002).

Book Chapter

Leduc P, Ostuni E, Whitesides GM, and IngberDE. Use of micropatterned adhesive surfaces for control of cell behavior. In: Adams J ed. Methods in Cell Biology. San Diego: Academic Press, 2002; 385-401.

Book Review

Ingber DE. Putting the cell biology establishment on the stand. Cell 109:688-689. 2002


Flusberg DA, Numaguchi Y, Ingber DE. Cooperative control of Akt phosphorylation and apoptosis by cytoskeletal microfilaments and microtubules. Mol. Biol. Cell 12: 3087-3094 (2001).

Whitesides GM, Ostuni E, Takayama S, Jiang X, Ingber DE. Soft lithography in Biology and Biochemistry. Ann. Rev. Biomed. Eng. 3: 335-373 (2001).

Wang N, Naruse K, Stamenovic D, Fredberg J, Mijailovic SM, Maksym G, Polte T, Ingber DE. Mechanical behavior in living cells consistent with the tensegrity model. Proc. Natl. Acad. Sci. U.S.A. 98: 7765-7770 (2001).

Takayama S, Ostuni E, LeDuc P, Naruse K, Ingber DE, Whitesides GM. Subcellular positioning of small molecules. Nature 411:1016 (2001).

Takayama S, Ostuni E. Qian X, McDonald JC, Jiang X, Wu M-H, Leduc P, Ingber DE, Whitesides GM. Topographical micropatterning of poly(dimethylsiloxane) using laminar flows of liquids in capillaries. Adv. Materials 13: 570-574 (2001).

Ostuni E, Chen CS, Ingber DE, Whitesides GW. Selective deposition of proteins and cells in arrays of microwells. Langmuir 17: 2828-2834 (2001).


Ingber DE, Heidemann SR, Lamoureux P, Buxbaum RE. Opposing views on tensegrity as a structural framework for understanding cell mechanics. J. Appl. Physiol. 89: 1663-1678 (2000).

Alenghat FJ, Fabry B, Tsai K, Goldmann WH, Ingber DE. Analysis of cell mechanics in single vinculin-deficient cells using a magnetic tweezer. Biochem. Biophys. Res. Comm. 277(1): 93-99 (2000).

Chen CS, Ostuni E, Whitesides GM, Ingber DE. Using self-assembled monolayers to pattern ECM proteins and cells on substrates. Methods Mol. Biol. 139: 209-219 (2000).

Huang S, Ingber DE. Shape-dependent control of cell growth, differentiation, and apoptosis: switching between attractors in cell regulatory networks. Exp. Cell Res. 261: 91-103 (2000).

Ingber DE. The origin of cellular life. Bioessays 22: 1160-1170 (2000).

Brangwynne C, Huang S, Parker KK, Ostuni E, Ingber DE. Symmetry-breaking in mammalian cell populations migrating in vitro. In Vitro Cell Dev. Biol. 36: 563-565 (2000).

Ferri KF, Jacotot E, LeDuc P, Geuskens M, Ingber DE, Kroemer G. Apoptosis of syncytia induced by the HIV-1-envelope glycoprotein complex: influence of cell shape and size. Exp.Cell Res. 261: 119-126 (2000).

Ostuni E, Kane R, Chen CS, Ingber DE, Whitesides GM. Patterning mammalian cells using elastomeric membranes. Langmuir 16: 7811-7819 (2000).

Meyer CJ, Alenghat FJ, Rim P, Fong JH-J, Fabry B, Ingber DE. Mechanical control of cyclic AMP signalling and gene transcription through integrins. Nature Cell Biol. 2: 666-668 (2000).

Yan L, Moses MA, Huang S, Ingber DE. Integrin-dependent control of matrix metalloproteinase activation in human capillary endothelial cells. J. Cell Sci. 113: 3979-3987 (2000).

Chiu DT, Jeon N L, Huang S, Kane R, Wargo C J, Choi I S, Ingber DE, Whitesides GM. Patterned deposition of cells and proteins onto surfaces using three-dimensional microfluidic systems. Proc. Nat. Acad. Sci. U.S.A. 97: 2408-2413 (2000).

Book Chapters

Ingber DE. Mechanical and chemical determinants of tissue development. In: Lanza RP, Langer R, Vacanti JP, eds. Principles of Tissue Engineering, second edition. San Diego, California: Academic Press 2000; 101-108.

Ingber DE. Biological design principles that guide self-organization, emergence, and hierarchical assembly: from complexity to tensegrity. In: Unifying Themes in Complex Systems: Proceedings of the First International Conference on Complex Systems. New York: Perseus Publishing; 2000.

Kane RS, Stroock A, Jeon NL, Ingber DE and Whitesides GM. Soft Lithography and Microfluidics. In: Ligler F and Taitt CR, eds., Optical Biosensors: Present and Future. Amsterdam, Elsevier Press, 2000; 571-595.


Ingber DE. Tensegrity and the emergence of complex mechanical behavior in living cells. Proceeding for the International Mechanical Engineering Congress and Exposition. Nov. 5-10, 2000; Orlando, FL.

Taayama S, Ostuni E. Qian X, McDonald JC, Jiang X, Wu M-H, Leduc P, Ingber DE and Whitesides GM. Patterning the topographical environment for mammalian cell culture using laminar flows in capillaries. Proceeding for the 1st Annual International IEEE-EMBS Conference on Microtechnologies in Medicine & Biology, Oct. 12-14, 2000, Lyon, France.


Huang S, Ingber DE. The structural and mechanical complexity of cell growth control. Nature Cell Biol. 1: E131-E138 (1999).

Ingber DE. How cells (might) sense microgravity. FASEB J. 13: 3-15 (May 1999).

Chen CS, Ingber DE. Tensegrity and mechanoregulation: from skeleton to cytoskeleton. Osteoarthritis Cartilage, 7/1: 81-94 (1999).

Chen CS, Brangwynne C, Ingber DE. Pictures in cell biology: squaring up to the cell shape debate. Trends Cell Biol. 9: 283 (1999).

Kane R, Takyama S, Ostuni E, Ingber DE, Whitesides. Patterning proteins and cells using soft lithography. Biomaterials 20: (23-24) 2363-2376 (1999).

Zhao H, Bojanowski K, Ingber DE, Panigrahy D, Pepper MS, Montesano R, and Shing Y. A new role for tRNA and its fragment purified from human urinary bladder carcinoma conditioned medium: inhibition of endothelial cell growth. J. Cell. Biochem. 76: 109-117 (1999).

Gechtman Z, Alonso JL, Raab G, Ingber DE, Klagsbrun M. The shedding of membrane-anchored heparin-binding epidermal-like growth factor is regulated by the Raf/mitogen-activated protein kinase cascade and by cell adhesion and spreading. J. Biol.Chem. 274: 28828-28835 (1999).

Dike L., Chen CS, Mrkisch M, Tien J, Whitesides GM, Ingber DE. Geometric control of switching between growth, apoptosis, and differentiation during angiogenesis using micropatterned substrates. In Vitro Cell Dev. Biol. 35: 441-448 (1999).

Book Chapter

Goldmann W, Alonso JL, Bojanowski K, Brangwynne C, Chen CS, Chicurel M, Dike L, Huang S, Kyung ML, Maniotis A, Mannix R, McNamee H, Meyer C, Naruse K, Parker KK, Plopper G, Polte T, Wang N, Yan L, Ingber DE. Cell Shape Control and Mechanical Signaling through the Cytoskeleton. In: Carraway, K, ed. The Cytoskeleton and Signaling: A Practical Approach. Oxford, England: Oxford University Press 1999; 245-276


Oslakovic K, Matsuura, R, Kumailil J, Roberts E, Vaughn D, Clifford D, Ezzell R, and Ingber DE. Cell-based biomimetic materials. Proceedings of the International Conference on Intelligent Materials. Gobin & Tatibouet, ed. Japan: Technomics; 1999


Ingber DE. The Architecture of Life. Jan 1998.

Ingber DE. In search of cellular control: signal transduction in context. J. Cell Biochem. 30/31: 232-237 (1998).

Chen CS, Mrksich M, Huang S, Whitesides GM, Ingber DE. Micropatterned surfaces for control of cell shape, position, and function. Biotech. Prog. 14:356-363 (1998).

Chicurel M, Chen CS, Ingber DE. Cellular control lies in the balance of forces. Curr. Opin. Cell Biol. 10:232-239 (1998).

Ingber DE. The cellular basis of mechanotransduction. In: The Cytoskeleton: Mechanical, Physical, and Biological Interactions; Proceedings from the 1996 NASA Symposium, Marine Biological Laboratory, Woods Hole, MA. Biol. Bull. 194: 323-325 (1998).

Huang S, Chen CS, Ingber DE. Control of cyclin D1, p27Kip1 and cell cycle progression in human capillary endothelial cells by cell shape and cytoskeletal tension. Mol. Biol. Cell 9: 3179-3193 (1998).

Bojanowski K, Ingber DE. Ionic control of chromosome architecture in living and permeabilized cells. Exp. Cell Res. 244:286-294 (1998).

Cai S, Pestic-Dragovich L, O’Donnell ME, Wang N, Ingber DE, Elson E, de Lanerolle P. Regulation of cytoskeletal mechanics and cell growth by myosin light chain phosphorylation. Am. J. Physiol. 275: C1349-C1356 (1998).

Roberts C, Chen CS, Mrksich M, Martichonok V, Ingber DE, Whitesides GM. Using mixed self assembled monolayers presenting GRGD and EG3OH groups to characterize long-term attachment of bovine capillary endothelial cells to surfaces. J. Am. Chem. Soc. 120: 6548-6555 (1998).

Eckes B, Dogic D, Colucci-Guyon E, Wang N, Maniotis A, Ingber DE, Merckling A, Aumailley M, Koteliansky V, Babinet C, Krieg T. Impaired mechanical stability, migration, and contractile capacity in vimentin-deficient fibroblasts. J. Cell Sci. 111: 1897-1907 (1998).

Pourati J, Maniotis A, Speigel D, Schaffer JL, Butler JP, Fredberg JJ, Ingber DE, Stamenovic D, Wang N. Is cytoskeletal tension a major determinant of cell deformability in adherent endothelial cells? Am. J. Physiol. 274: C1283-C1289 (1998).

Chicurel ME, Singer RH, Meyer C, Ingber DE. Integrin binding and mechanical tension induce movement of mRNA and ribosomes to focal adhesions. Nature 392: 730-733 (1998).

Bojanowski K, Maniotis A, Plisov S, Larsen AK, Ingber DE. DNA Topoisomerase II can drive changes in higher order chromosome architecture without enzymatically modifying DNA. J. Cell. Biochem. 69: 127-142 (1998).

Lee K-M, Tsai K, Wang N, Ingber DE. Extracellular matrix and pulmonary hypertension: control of vascular smooth muscle cell contractility. Am. J. Physiol. 274 (Heart Circ. Physiol. 43): H76-H82 (1998).

Book Chapter

Fredberg JJ, Wang N, Stamenovic D, Ingber DE. Micromechanics of the lung: from the parenchyma to the cytoskeleton. In: Hlastala MP, Robertson T, eds. Complexity in Structure and Function of the Lung. New York: Marcel Dekker; 1998; 99-122.


Ingber DE. Integrins, tensegrity, and mechanotransduction. Grav. and Space Biol. Bull. 1997;10:49-55.

Ingber DE. Tensegrity: the architectural basis of cellular mechanotransduction. Annu. Rev. Physiol. 1997; 59:575-599.

Mrksich M, Dike LE, Tien J, Ingber DE, Whitesides GM. Using microcontact printing to pattern the attachment of mammalian cells to self-assembled monolayers of alkanethiolates on transparent films of gold and silver. Exp. Cell Res. 1997; 235:305-313.

Chen CS, Mrksich M, Huang S, Whitesides G, Ingber DE. Geometric control of cell life and death. Science 1997; 276:1425-1428.

Planus E, Barlovatz-Meimon G, Rogers RA, Bonavaud S, Ingber DE, Wang N. Binding of urokinase to plasminogen activator inhibitor type 1 mediates cell adhesion and spreading. J. Cell Sci. 1997; 110:1091-1098.

Tagawa H, Wang N, Narishige T, Ingber DE, Zile MR, Cooper IV G. Cytoskeletal Mechanics Pressure Overload Cardiac Hypertrophy. Circ. Res. 1997; 80:281-289

Ezzell RM, Goldmann WH, Wang N, Parasharama N, Ingber DE. Vinculin promotes cell spreading by mechanically coupling integrins to the cytoskeleton. Exp. Cell Res. 1997; 231: 14-26.

Maniotis A, Bojanowski K, Ingber DE. Mechanical continuity and reversible chromosome disassembly within intact genomes microsurgically removed from living cells. J. Cell. Biochem. 1997; 65:114-130.

Maniotis A, Chen C, Ingber DE. Demonstration of mechanical connections between integrins, cytoskeletal filaments and nucleoplasm that stabilize nuclear structure. Proc. Natl. Acad. Sci. U.S.A. 1997; 94:849-854.

Book Chapters

Ingber DE. Mechanochemical switching between growth and differentiation by extracellular matrix. In: Lanza RP, Langer R, Chick WL, eds. Textbook of Tissue Engineering. Austin, Texas: R.G. Landes Co.; 1997; 89-100.

Ingber DE. Engineering cell shape and function through control of substrate adhesion. In: Mittal KL, Lee KW, eds. Polymer Surfaces and Interfaces. Utrecht, The Netherlands: VSP; 1997; 413-424.

Ingber DE. Extracellular matrix: a solid-state regulator of cell form, function, and tissue development. In: Jamieson JD, Hoffman JF, eds. Handbook of Cell Physiology. New York: Oxford University Press; 1997; 541-556.

Ingber DE. Discovery of TNP-470 and other angiogenesis inhibitors. In: Teicher BA, ed. Cancer Therapeutics: Experimental and Clinical Agents. Totowa, NJ: Human Press Inc.; 1997; 283-298.

Ingber DE. Tensegrity and the Emergence of a Cellular Biophysics. In: Proceedings of the Les Houches Meeting on Dynamical Networks in Physics and Biology. France: Springer Verlag; 1997


Dike L, Ingber DE. Integrin-dependent induction of early growth response genes in capillary endothelial cells. J. Cell Sci. 1996; 109:2855-2863.

Mrksich M, Chen CS, Xia Y, Dike LE, Ingber DE, Whitesides GM. Controlling cell attachment on contoured surfaces with self-associated monolayers of alkanethiolates on gold. Proc. Natl. Acad. Sci. U.S.A.. 1996; 93:10775-10778.

Stamenovic D, Fredberg J, Wang N, Butler J, Ingber DE. A microstructural approach to cytoskeletal mechanics based on tensegrity. J. Theor. Biol. 1996; 181:125-136.

Yoshida M, Westlin WF, Wang N, Ingber DE, Rosenweig A, Resnick N, Gimbrone M. Leukocyte adhesion to vascular endothelium induces e-selectin association with the actin cytoskeleton. J. Cell Biol. 1996; 133:445-455.

Fong J-H, Ingber DE. Modulation of adhesion-dependent signaling by echistatin and alendronate. Biochem. Biophys. Res. Comm. 1996; 221:19-24.

McNamee HP, Liley HG, Ingber DE. Integrin-dependent control of inositol lipid synthesis in vascular endothelial cells and smooth muscle cells. Exp. Cell Res. 1996; 224:116-122.


Kieffer JD, Plopper G, Ingber DE, Hartwig JH, Kupper TS. Direct binding of F-actin to the cytoplasmic domain of the a2 integrin chain in vitro. Biochem. Biophys. Res. Comm. 1995; 217:466-474.

Wang N, Ingber DE. Probing transmembrance mechanical coupling and cytomechanics using magnetic twisting cytometry. Biochem. Cell Biol. 1995; 73:1-9.

Ingber DE, Prusty D, Sun Z, Betensky H, Wang N. Cell shape, cytoskeletal mechanics and cell cycle control in angiogenesis. J. BioMech. 1995; 28:1471-1484.

Plopper G, McNamee H, Dike L, Bojanowski K, Ingber DE. Convergence of integrin and growth factor receptor signaling pathways within the focal adhesion complex. Mol. Biol.Cell 1995; 6:1349-1365.

Mooney D, Langer R, Ingber DE. Cytoskeletal filament assembly and the control of cell shape and function by extracellular matrix. J. Cell Sci. 1995; 108:2311-2320.


Schwartz MA, Ingber DE. Integrating with Integrins. Mol. Biol. Cell 1994; 5:389-393.

Ingber DE, Dike L, Hansen L, Karp S, Liley H, Maniotis A, McNamee H, Mooney D, Plopper G,Sims J, and Wang N. Cellular tensegrity: exploring how mechanical changes in the cytoskeleton regulate cell growth, migration, and tissue pattern during morphogenesis. Int. Rev. Cytol. 1994;150:173-224.

Wong J, Langer R, Ingber DE. Cell interactions with fibronectin-coated electrically conducting polypyrrole thin films. Mater. Res. Soc. Proc. 1994; 331:141-145.

Mooney D, Hansen L, Langer R, Vacanti JP, Ingber DE. Extracellular matrix controls tubulin monomer levels in hepatocytes by regulating protein turnover. Mol. Biol. Cell 1994; 5:1281-1288.

Hansen L, Mooney D, Vacanti JP, Ingber DE. Integrin binding and cell spreading on extracellular matrix act at different points in the cell cycle to promote hepatocyte growth. Mol. Biol. Cell 1994; 5:967-975.

Yang, MB, Vacanti, JP, Ingber DE. Hollow fibers for hepatocyte encapsulation and transplantation: studies of survival and function in rats. Cell Transplant. 1994; 3:373-385.

Wang N, Ingber DE. Control of cytoskeletal mechanics by extracellular matrix, cell shape, and mechanical tension. Biophys. J. 1994; 66:2181-2189.

Kusaka M, Sudo K, Matsutani E, Kozai Y, Marui S, Fujita T, Ingber DE, Folkman J. Cytostatic inhibition of endothelial cell growth by the angiogenesis inhibitor, TNP-470 (AGM-1470). Br. J. Cancer 1994; 69:212-216.

Wong JY, Langer RS, Ingber DE. Electrically conducting polymers can non-invasively control the shape and growth of mammalian cells. Proc. Natl. Acad. Sci. U.S.A. 1994; 91:3201-3204.

Singhvi R, Kumar A, Lopez G, Stephanopoulos GN, Wang DIC, Whitesides GM, Ingber DE. Engineering cell shape and function. Science 1994; 264:696-698.

Book Chapter

Ingber DE. Cellular Tensegrity and Mechanochemical transduction. In: Mow VC, Hochmuth R Guilak F, Tran Son-Tay R, eds. Cell Mechanics and Cellular Engineering. New York: Springer-Verlag; 1994; 329-342.


Wong JY, Langer RS, Ingber DE. Characterization of electrically conducting polypyrrole thin films for protein adsorption and cell attachment. Polymer Preprints 1993; 34:60-66.

Wong JY, Langer RS, Ingber DE. Cell attachment and protein adsorption to polypyrrole thin films. Mat. Res. Soc. Proc. 1993; 293:179-184.

Fontaine MJ, Hansen LK, Thompson S, Uyama S, Ingber DE, Langer R, Vacanti JP. Transplantation of genetically altered hepatocytes using cell-polymer constructs. Transplant Proc. 1993; 25:1002-1004.

Mikos AG, Bao Y, Cima LG, Ingber DE, Vacanti JP, Langer R. Preparation of poly(glycolic acid) bonded fiber structures for cell attachment and transplantation. J. Biomed. Mater. Res. 1993; 27:183-189.

Mikos AG, Sarakinos G, Lyman MD, Ingber DE, Vacanti JP, Langer R. Prevascularization of porous biodegradable polymers. Biotech. Bioengin. 1993; 42:716-723.

Ingber DE. The riddle of morphogenesis: a question of solution chemistry or molecular cell engineering? Cell 1993; 75:1249-1252.

Wang N, Butler JP, Ingber DE. Mechanotransduction across the cell surface and through the cytoskeleton. Science 1993; 260:1124-1127.

Plopper, G, Ingber DE. Rapid induction and isolation of focal adhesion complexes. Biochem. Biophys. Res. Commun. 1993; 193:571-578.

McNamee H, Ingber DE, Schwartz M. Adhesion to fibronectin stimulates inositol lipid synthesis and enhances PDGF-induced inositol lipid breakdown. J. Cell Biol. 1993; 121:673-678.

Ingber, DE. Cellular Tensegrity: defining new rules of biological design that govern the cytoskeleton. J. Cell Sci. 1993; 104:613-627.

Book Chapters

Ingber DE. Extracellular matrix, cellular mechanics, and tissue engineering. In: Bell E, ed. Tissue Engineering: Current Perspectives. Boston: Birkhauser; 1993; 69-82.

Ingber DE. Extracellular matrix as a regulator of epithelial cell polarity, growth, and tissue pattern. In: Go VLW, Gardner J, Lebenthal E, Reber H, Scheele G, eds. The Pancreas. New York: Raven Press; 1993; 369-380.

Ingber DE. Extracellular matrix and the development of tissue architecture: a mechanochemical perspective. In: Zern MA, Reid LM, eds. The Extracellular Matrix: Chemistry, Biology, and Pathobiology with Emphasis on the Liver. New York: Marcel Dekker; 1993; 403-428.

Ingber DE, Karp S, Plopper G, Hansen L, Mooney D. Mechanochemical transduction across extracellular matrix and through the cytoskeleton. In: Frangos JA, Ives CL, eds. Physical Forces and the Mammalian Cell. San Diego: Academic Press; 1993; 61-79.


Mikos AG, Sarakinos G, Lyman MD, Ingber DE, Vacanti JP, Langer L. Prevascularization of biodegradable polymer scaffolds for hepatocyte transplantation. Polymer Materials Sci. Eng. Preprints. 1992; 66:34-35.

Mooney DJ, Cima L, Langer R, Johnson L, Hansen LK, Ingber DE, Vacanti JP. Principles of tissue engineering and reconstruction using polymer-cell constructs. Mater. Res. Soc. Proc. 1992; 252:345-353.

Mooney DJ, Langer R, Hansen LK, Vacanti JP, Ingber DE. Induction of hepatocyte differentiation by the extracellular matrix and an RGD-containing synthetic peptide. Mater. Res. Soc. Proc. 1992; 252:199-204.

Sims J, Karp S, Ingber DE. Altering the cellular mechanical force balance results in integrated changes in cell, cytoskeletal, and nuclear shape. J. Cell Sci. 1992; 103:1215-1222.

Mooney, D, Hansen, L, Farmer, S, Vacanti, J, Langer R, Ingber, DE. Switching from differentiation to growth in hepatocytes: control by extracellular matrix. J. Cell Physiol. 1992; 151:497-505.

Brem H, Ingber DE, Blood CH, Bradley D, Urioste S, Folkman J. Suppression of tumor metastasis by angiogenesis inhibition. Surg. Forum 1992; 42:439-441.

Folkman J, Ingber DE. Inhibition of Angiogenesis. Semin. Cancer Biol. 1992; 3:89-96.

Ingber DE. Extracellular matrix as a solid state regulator of angiogenesis: identification of new targets for anti-cancer therapy. Semin. Cancer Biol. 1992; 3:57-63.

Book Chapter

Hansen LK, Ingber DE. Regulation of nucleocytoplasmic transport by mechanical forces transmitted through the cytoskeleton. In: Feldherr C, ed. Nuclear Trafficking. San Diego: Academic Press; 1992; 71-86.


Ingber DE. Extracellular matrix and cell shape: potential control points for inhibition of angiogenesis. J. Cell. Biochem. 1991; 47:236-241.

Ingber DE. Control of capillary growth and differentiation by extracellular matrix: use of tensegrity (tensional integrity) mechanism for signal processing. Chest 1991; 99:34-40.

Ingber DE. Tumor, angiogenesis, and fumagillin. Biomed. Pharmacoth. 1991; 45:464.

Ingber DE. Integrins as mechanochemical transducers. Curr. Opin. Cell Biol. 1991; 3:841-848.

Cima L, Vacanti J, Vacanti C, Mooney D, Ingber DE, Langer R. Tissue Engineering by Cell Transplantation using degradable polymer substrates. J. Biomech. Eng. 1991; 113:143-151.

Cima L, Ingber DE, Vacanti J, Langer R. Hepatocyte culture on biodegradable substrates. Biotech. Bioengineer. 1991; 38:145-158.

Kusaka M, Sudo K, Fujita T, Marui S, Itoh F, Ingber DE, Folkman J. Potent anti-angiogenic action of AGM-1470: comparison to the fumagillin parent. Biochem. Biophys. Res. Comm. 1991; 174:1070-1076.

Schwartz, MA, Lechene, C, Ingber, DE. Insoluble fibronectin activates the Na+/H+ antiporter by clustering and immobilizing integrin a5 b1, independent of cell shape. Proc. Natl. Acad. Sci. U.S.A. 1991; 88:7849-7853.

Schwartz MA, Ingber DE, Laurence M, Springer TA, Lechene C. Multiple integrins share the ability to induce elevation of intracellular pH. Exp. Cell Res. 1991; 195:533-535.


Ingber DE, Fujita T, Kishimoto S, Kanamaru T, Sudo K, Brem H, Folkman J. Synthetic analogues of fumagillin which inhibit angiogenesis and suppress tumour growth. Nature 1990; 348:555-557.

Ingber DE, Prusty, D, Frangione J, Cragoe EJ Jr, Lechene C, Schwartz M. Control of intracellular pH and growth by fibronectin in capillary endothelial cells. J. Cell Biol. 1990; 110:1803-1812.

Ingber DE. Fibronectin controls capillary endothelial cell growth by modulating cell shape. Proc. Natl. Acad. Sci. U.S.A. 1990; 87:3579-3583.

Book Chapter

Ingber DE. Control of Fibroblast Growth Factor Action by Extracellular Matrix. In: Westermark B, Betsholtz C, Hokfelt B, eds. Growth Factors in Health and Disease: Basic and Clinical Aspects. Amsterdam: Elsevier; 1990; 289-302.


Whalen G, Ingber DE. Inhibition of tumor cell attachment to extracellular matrix as a method for preventing tumor recurrence in a surgical wound. Ann. Surg. 1989; 210:758-764.

Hoffer FA, Taylor GA, Spevak M, Ingber DE, Fenton T. Metabolism of tumor regression from angiogenesis inhibition: 31P magnetic resonance spectroscopy. Magn. Reson. Med. 1989; 11:202-208.

Ingber DE, Folkman J. How does extracellular matrix control capillary morphogenesis? Cell 1989; 58:803-805.

Ingber DE, Folkman J. Mechanochemical switching between growth and differentiation during fibroblast growth factor-stimulated angiogenesis in vitro: role of extracellular matrix. J. Cell Biol. 1989; 109:317-330.

Folkman J, Watson K, Ingber, DE, Hanahan, D. Induction of angiogenesis during the transition from hyperplasia to neoplasia. Nature 1989; 339: 58-61.

Book Chapters

Ingber DE, Folkman J. Tension and compression as basic determinants of cell form and function: utilization of a cellular tensegrity mechanism. In: Stein W, Bronner F, eds. Cell Shape: Determinants, Regulation and Regulatory Role. Orlando: Academic Press; 1989; 1-32.

Folkman J, Ingber DE. The role of heparin in regulation of angiogenesis. In: Lane DA, Lindahl U, eds. Heparin. London: Edward Arnold Ltd.; 1989; 317-333.

Folkman J, Ingber DE. Angiostatic steroids. In: Schleimer RP, Claman HN, Aronsky A, eds. Anti-inflammatory Steroid Action: Basic and Clinical Aspects. Orlando: Academic Press; 1989; 330-350.


Ingber DE, Folkman J. Inhibition of angiogenesis through inhibition of collagen metabolism. Lab. Invest. 1988; 59:44-51.

Folkman J, Klagsbrun MK, Sasse J, Wadzinski M, Ingber DE, Vlodavsky I. A heparin-binding angiogenic protein - basic fibroblast growth factor - is stored within basement membrane. Am. J. Pathol. 1988; 130: 393-400.

Book Chapter

Ingber DE, Folkman J. Extracellular matrix, endothelial cell shape modulation, and control of angiogenesis: potential targets for anti-tumor differentiation therapy. In: Waxman S, Rossi GB, Takaku F, eds. The Status of Differentiation Therapy of Cancer. New York: Raven Press; 1988;111-124.


Ingber DE, Madri JA, Folkman J. Extracellular matrix regulates endothelial growth factor action through modulation of cell and nuclear expansion. In Vitro Cell Dev. Biol. 1987; 23:387-394.

Wadzinski MG, Folkman J. Sasse J, Devey K, Ingber DE, Klagsbrun MK. Heparin binding angiogenesis factors: detection by immunological methods. Clin. Physiol. Biochem. 1987; 5:200-209.

Ingber DE, Folkman J. Regulation of endothelial growth factor action: solid state control by extracellular matrix. In Prog. Clin. Biol. Res. 1987; 279: 273-282.

Folkman J. Ingber DE. Angiostatic steroids: method of discovery and mechanism of action. Ann.Surg. 1987; 206:374-383.

Book Chapters

Folkman J, Ingber DE. Inhibitors of angiogenesis: angiostatic steroids. In: Rifkin D, Klagsbrun MK, eds. Angiogenesis: Mechanisms and Pathology. Cold Spring Harbor: Cold Spring Harbor Press; 1987;95-100.

Thompson RW, Folkman J, Langer R, Ingber DE, Sudhalter J, D'Amore PA. Angiogenic vascular grafts. In: Zilla F, Faso G, Deutsch F, eds. Endothelialization of Vascular Grafts. Basel: Karger; 1987; 167-176.


Ingber DE, Madri JA, Jamieson JD. Basement membrane as a spatial organizer of polarized epithelia:exogenous basement membrane reorients pancreatic epithelial tumor cells in vitro. Am. J. Pathol. 1986; 122:129-139.

Ingber DE, Madri JA, Folkman J. A possible mechanism for inhibition of angiogenesis by angiostatic steroids:induction of capillary basement membrane dissolution. Endocrinol. 1986; 119:1768-1775.


Ingber DE, Madri JA, Jamieson JD. Neoplastic disorganization of pancreatic epithelial cell-cell relations: role of basement membrane. Am. J. Pathol. 1985;121:248-260.

Book Chapter

Ingber DE, Jamieson JD. Cells as tensegrity structures: architectural regulation of histodifferentiation by physical forces tranduced over basement membrane. In: Andersson LC,Gahmberg CG, Ekblom P, eds. Gene Expression During Normal and Malignant Differentiation. Orlando: Academic Press; 1985; 13-32.



Ingber DE. Basement membrane polarizes epithelial cells and its loss can result in neoplastic disorganization [Ph.D. Dissertation]. New Haven, Connecticut: Yale University; 1984; 182p.


Book Chapter

Ingber DE, Jamieson JD. Tumor formation and malignant invasion: role of basal lamina. In: Liotta LA, Hart IR, eds. Tumor Invasion and Metastasis. The Hague, Netherlands: Martinus Nijhoff; 1982; 335-357.


Jamieson JD, Ingber DE, Muresan V, Sarras MP Jr, Maylie-Pfenninger MF, Lwanij V. Cell surface properties of normal, differentiating, and neoplastic pancreatic acinar cells. Cancer 1981; 47:1516-1525.

Ingber DE, Madri JA, Jamieson JD. Role of basal lamina in the neoplastic disorganization of tissue architecture. Proc. Natl. Acad.Sci. U.S.A. 1981; 78:3901-3905.


Book Chapter

Jamieson JD, Muresan V, Ingber DE, Iwanij V, Sarras MP Jr, Maylie-Pfenninger M-F. Differentiation of plasmalemmal saccharides in embryonic pancreatic cells. In: Ribet A, Pradayrol L, Susini C, eds. Biology of Normal and Cancerous Exocrine Pancreatic Cells. Amsterdam: Elsevier/North Holland; 1980; 199-206.


Lazo JS, Ingber DE, Sartorelli AC. Enhancement of experimental lung metastases by cultured B16 melanoma cells treated with (+)-1, 2-bis(3,5-dioxopiperazin-1-y1)propane(ICRF 159). Cancer Research 1978; 38:2263-2279.

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