Infantile hemangiomas are the most common tumors of infancy, affecting 4-10% of Caucasian infants. They are benign vascular endothelial cell neoplasms which grow rapidly during infancy and involute slowly during childhood. Infantile Hepatic Hemangiomas, like their more common cutaneous counterparts, demonstrate characteristic phases of development. It is probable that most hepatic hemangiomas are clinically silent and, therefore, remain undetected prior to undergoing their predictable regression and involution during early childhood. A subset of hemangiomas become symptomatic, manifesting as cardiac failure secondary to high volume shunting, hypothyroidism secondary to overproduction of type III iodothyronine deiodinase, fulminant hepatic failure, and/or abdominal compartment syndrome.
We hypothesize that the behavior of hepatic hemangiomas may be predicted by studying their physiologic features and biologic activity and hope to be able to select more rational and directed therapeutic options through an increased understanding of potential hemangioma subtypes.
The infantile hepatic hemangioma registry attempts to collect information regarding the radiographic, physiologic, and biochemical presentation of hepatic hemangiomas and follow their clinical progression and response to treatment in exchange for expert consultation from a multidisciplinary team of physician members of the Vascular Anomalies Center at Children's Hospital Boston.
This site is for physicians. If you are not a physician, but are interested in having an infant enrolled in the registry, please refer your pediatrician to this site.
For physicians who would like access to and more information about the Hepatic Hemangioma Registry, please register to gain access to the data collection page.